Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID‐19 patients
نویسندگان
چکیده
منابع مشابه
Overlap between maculopapular exanthema and DRESS among cutaneous adverse drug reactions in a dermatology ward (2008-2012)
Results We analyzed 132 patients (85F/47M; mean age of 63.98 ±17.68 years) with maculopapular exanthema (MPE) (21.2%), DRESS (28.0%), overlap MP/DR (25.8%), Stevens-Johnson syndrome/toxic epidermal necrolysis (12.1%), acute generalized exanthematous pustulosis (8.3%), fixed drug eruption (3.78%) and urticaria/angioedema (0.76%), caused mainly by allopurinol (36.5%), antimicrobials (30.8%) and a...
متن کاملAssociation between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients
The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of t...
متن کاملGenetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients
OBJECTIVE To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. METHODS We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls fr...
متن کاملEffects of Pantoprazole on Systemic and Gastric Pro- and Anti-inflammatory Cytokines in Critically Ill Patients
Stress-related mucosal damage (SRMD) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. Prophylaxis of SRMD with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. Both demonstrated to be effective in reducing clinically significant bleedings, while PPIs has shown to exert some anti ...
متن کاملEffects of Pantoprazole on Systemic and Gastric Pro- and Anti-inflammatory Cytokines in Critically Ill Patients
Stress-related mucosal damage (SRMD) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. Prophylaxis of SRMD with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. Both demonstrated to be effective in reducing clinically significant bleedings, while PPIs has shown to exert some anti ...
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ژورنال
عنوان ژورنال: Allergy
سال: 2021
ISSN: 0105-4538,1398-9995
DOI: 10.1111/all.14983